Aromatase Inhibitors May Relieve Endometriosis-Associated Pain: ReviewMedscape (subscription) - Jun 20, 2008Symptoms include pelvic pain, dyspareunia, and painful bowel movements from cyclical bleeding and inflammation, which result in the formation of adhesions ...
Massage offers physical and mental benefits
Statesman Journal, OR - Jun 19, 2008... reduce scar tissue formation, improves circulation by increasing blood and nutrient flow to tissues, and reduce post surgery adhesions and swelling. ...
NeoMend Receives FDA Panel's Recommendation for Approval of ProGEL ...Earthtimes (press release), UK - Jun 17, 2008... is also developing a similar product, ProGEL-AB, for sealing surgical wound sites while also helping prevent the formation of post-surgical adhesions. ... Similar Outcomes for Patients After Laparoscopic and Open ...Abkhazia, CA - Jun 16, 2008... of incisional hernia, the number of reoperations for incisional hernia, or the number of reoperations for intraperitoneal adhesions, the authors report. ...
Haemacure Raises $7.8 Million and is Fully Funded Beyond First ...PharmaLive.com (press release), PA - Jun 16, 2008Follow-on development will focus on surgical hemostats, wound healing, adhesion prevention, regenerative medicine, drug delivery and combinations with ...TSE:HAE Haemacure Raises $7.8 Million and is Fully Funded Beyond First ...istockAnalyst.com, OR - Jun 16, 2008Follow-on development will focus on surgical hemostats, wound healing,adhesion prevention, regenerative medicine, drug delivery and combinationswith ...TSE:HAE
Sunday, June 22, 2008
Mom's the childish, egocentric oneSunHerald.com, MS - 9 hours agoI am a 6-foot-tall woman, and as a result of endometriosis, I have facial hair and a muscular build, too. After finding the right makeup, ...
Nitro dioxin report flawedCharleston Gazette, USA - 10 hours agoDioxin has been linked to cancer, birth defects, learning disabilities, endometriosis, infertility and suppressed immune functions. ...
Aromatase Inhibitors May Relieve Endometriosis-Associated Pain: ReviewMedscape (subscription) - Jun 20, 2008Describe the evidence supporting the use of aromatase inhibitors for endometriosis. Identify limitations of studies on the use of aromatase inhibitors for ...
Report On Presentations From The European Society For The Study Of ...Medical News Today (press release), UK - Jun 20, 2008Dr. Andrey Zaitcev and coworkers from Moscow presented a series of 19 women diagnosed with chronic pelvic pain from endometriosis who were subsequently ...
'Color Purple' -- or Is That Blue-and-White?Jewish Exponent, PA - Jun 19, 2008... including one which serves her as a spokeswoman in the battle against endometriosis, a gynecological problem she has dealt with in her life. ...
Nitro dioxin report flawedCharleston Gazette, USA - 10 hours agoDioxin has been linked to cancer, birth defects, learning disabilities, endometriosis, infertility and suppressed immune functions. ...
Aromatase Inhibitors May Relieve Endometriosis-Associated Pain: ReviewMedscape (subscription) - Jun 20, 2008Describe the evidence supporting the use of aromatase inhibitors for endometriosis. Identify limitations of studies on the use of aromatase inhibitors for ...
Report On Presentations From The European Society For The Study Of ...Medical News Today (press release), UK - Jun 20, 2008Dr. Andrey Zaitcev and coworkers from Moscow presented a series of 19 women diagnosed with chronic pelvic pain from endometriosis who were subsequently ...
'Color Purple' -- or Is That Blue-and-White?Jewish Exponent, PA - Jun 19, 2008... including one which serves her as a spokeswoman in the battle against endometriosis, a gynecological problem she has dealt with in her life. ...
Friday, June 20, 2008
Fluid and pharmacological agents for adhesion prevention after gynaecological surgery
Fluid and pharmacological agents for adhesion prevention after gynaecological surgery
Fluid and pharmacological agents for adhesion prevention after gynaecological surgeryThe use of fluids and pharmacological agents (medicinal drugs) to prevent the formation of adhesions (scar tissue) that may interfere with becoming pregnant after surgery of the female pelvis.Adhesion formation is a condition in which bodily tissues that are normally separate grow together. This can occur after surgical procedures such as operations on the female pelvis to remove a cyst, treat endometriosis, remove a tubal pregnancy, or remove a fibroid (a benign tumour of the womb). This scar tissue can have serious effects on the woman's future fertility as it can lead to blockage of her tubes. Careful tissue handling at the time of surgery and control of the blood loss are important ways of reducing scar tissue, however, over the years other methods have been developed to minimise the risk of scar tissue formation. Surgeons have tried using different types of drugs or leaving different types of fluids inside the pelvis at the end of surgery to prevent tissue surfaces from sticking to each other. Fluids include dextran, icodextrin (Adept), SprayGel, and fluids containing the chemical hyaluronic acid (Intergel, auto-crosslinked hyaluronic acid, Sepracoat). Drugs that have been tried include steroids (anti-inflammatory drug), the anti-coagulant heparin, promethazine, and noxytioline.This review aimed to evaluate the role of these different agents in the prevention of adhesion formation. The results showed that there is currently insufficient evidence to recommend the use of steroids, icodextrin, SprayGel or dextran. The review did show that fluids that contained hyaluronic acid may help lower the chance of scar tissue forming; however, more studies are needed to confirm this. There are also some major safety issues concerning the use of one of these agents (Intergel), which has been withdrawn from the market due to reports of serious side effects such as allergic reactions and pain.A major problem with studies in this review is that most of them did not look at the rate of pregnancy following the use of these substances. Since the occurrence of pregnancy is the gold standard for measuring how well these agents work to preserve fertility, it is important that future studies take this into consideration.http://www.cochrane.org/reviews/en/ab001298.htmlMain resultsThere is no evidence of benefit from the use of steroids, dextran or other pharmacological agents in any of the outcomes. The use of hyaluronic acid agents may decrease adhesion formation (OR 0.31, 95% CI 0.19 to 0.51) and prevent the deterioration of pre-existing adhesions (OR 0.28 (95% CI 0.12 to 0.66). There is insufficient evidence for the use of icodextrin 4% or SprayGel as adhesion-preventing agents. None of the studied agents has been shown to improve the pregnancy rate when used as an adjunct during pelvic surgery.Authors' conclusionsThe current evidence for the use of fluid and pharmacological agents for the prevention of adhesions is limited. There is no evidence on any benefit for improving pregnancy outcomes when pharmacological and fluid agents are used as an adjunct during pelvic surgery.There is insufficient evidence for the use of the following agents: steroids, icodextrin 4%, SprayGel and dextran in improving adhesions following surgery.There is some evidence that hyaluronic acid agents may decrease the proportion of adhesions and prevent the deterioration of pre existing adhesions. However, due to the limited number of studies available, this evidence should be interpreted with caution and further studies are needed.Full studyhttp://mrw.interscience.wiley.com/cochrane/clsysrev/articles/CD001298/frame.htmland who do they as one of the references??????METTLER!!!!
Posted by IHRT at 6/20/2008 01:26:00 PM 0 comments Links to this post
Labels: Adept, adhesion barrier, adhesion prevention, Adhesion related disorders, adhesions, endometriosis, postoperative complications, SprayGel, surgeons, surgery
Fluid and pharmacological agents for adhesion prevention after gynaecological surgeryThe use of fluids and pharmacological agents (medicinal drugs) to prevent the formation of adhesions (scar tissue) that may interfere with becoming pregnant after surgery of the female pelvis.Adhesion formation is a condition in which bodily tissues that are normally separate grow together. This can occur after surgical procedures such as operations on the female pelvis to remove a cyst, treat endometriosis, remove a tubal pregnancy, or remove a fibroid (a benign tumour of the womb). This scar tissue can have serious effects on the woman's future fertility as it can lead to blockage of her tubes. Careful tissue handling at the time of surgery and control of the blood loss are important ways of reducing scar tissue, however, over the years other methods have been developed to minimise the risk of scar tissue formation. Surgeons have tried using different types of drugs or leaving different types of fluids inside the pelvis at the end of surgery to prevent tissue surfaces from sticking to each other. Fluids include dextran, icodextrin (Adept), SprayGel, and fluids containing the chemical hyaluronic acid (Intergel, auto-crosslinked hyaluronic acid, Sepracoat). Drugs that have been tried include steroids (anti-inflammatory drug), the anti-coagulant heparin, promethazine, and noxytioline.This review aimed to evaluate the role of these different agents in the prevention of adhesion formation. The results showed that there is currently insufficient evidence to recommend the use of steroids, icodextrin, SprayGel or dextran. The review did show that fluids that contained hyaluronic acid may help lower the chance of scar tissue forming; however, more studies are needed to confirm this. There are also some major safety issues concerning the use of one of these agents (Intergel), which has been withdrawn from the market due to reports of serious side effects such as allergic reactions and pain.A major problem with studies in this review is that most of them did not look at the rate of pregnancy following the use of these substances. Since the occurrence of pregnancy is the gold standard for measuring how well these agents work to preserve fertility, it is important that future studies take this into consideration.http://www.cochrane.org/reviews/en/ab001298.htmlMain resultsThere is no evidence of benefit from the use of steroids, dextran or other pharmacological agents in any of the outcomes. The use of hyaluronic acid agents may decrease adhesion formation (OR 0.31, 95% CI 0.19 to 0.51) and prevent the deterioration of pre-existing adhesions (OR 0.28 (95% CI 0.12 to 0.66). There is insufficient evidence for the use of icodextrin 4% or SprayGel as adhesion-preventing agents. None of the studied agents has been shown to improve the pregnancy rate when used as an adjunct during pelvic surgery.Authors' conclusionsThe current evidence for the use of fluid and pharmacological agents for the prevention of adhesions is limited. There is no evidence on any benefit for improving pregnancy outcomes when pharmacological and fluid agents are used as an adjunct during pelvic surgery.There is insufficient evidence for the use of the following agents: steroids, icodextrin 4%, SprayGel and dextran in improving adhesions following surgery.There is some evidence that hyaluronic acid agents may decrease the proportion of adhesions and prevent the deterioration of pre existing adhesions. However, due to the limited number of studies available, this evidence should be interpreted with caution and further studies are needed.Full studyhttp://mrw.interscience.wiley.com/cochrane/clsysrev/articles/CD001298/frame.htmland who do they as one of the references??????METTLER!!!!
Posted by IHRT at 6/20/2008 01:26:00 PM 0 comments Links to this post
Labels: Adept, adhesion barrier, adhesion prevention, Adhesion related disorders, adhesions, endometriosis, postoperative complications, SprayGel, surgeons, surgery
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