Endometriosis ~ Abdominal Pain ~ Endo ~ Scar Tissue ~ Adhesions ~ Infertility ~ Hysterectomy

Monday, September 22, 2008

Out-of-control enzyme may trigger endometriosis

A news flash from Stephanie St. James

Out-of-control enzyme may trigger endometriosis
Scientists may be one step closer to solving the mystery behind endometriosis — what doctors say is a common health problem for women. In their latest study, scientists at the University of Liverpool in the UK have discovered what may be triggering this condition. Their findings were recently published in the journal Human Reproduction.

The telomeres enable egg cells to continue dividing
© Shutterstock

'Endometriosis occurs when cells of the inner lining of the womb are found growing outside of the uterus,' explained Dr Dharani Hapangama from the Department of Reproductive and Developmental Medicine, University of Liverpool. 'At the time of a woman's menstruation cycle these cells, called endometrial cells, are shed and can be expelled into the abdominal cavity,' he said. 'If these cells continue to live and are implanted in the pelvis and abdomen it can cause severe pain and in serious cases can lead to infertility.'

The telomerase enzyme, found in cells and the inner lining of the womb, patrols the end parts of chromosomes, called telomeres. These telomeres hold the two ends of the chromosomes together and ensure that they stay intact during cell division. The researchers found that telomerase is released by cells in the inner lining of the womb at the beginning and towards the end of the menstrual cycle in women suffering from this condition. Cancer cells also contain this enzyme, which seemingly replicates DNA sequences during cell division in chromosomes, experts say.

The lead researcher went on to say that the team found the telomere to be unusually long in women with endometriosis. 'During menstruation, telomeres normally shorten in length with each cycle of cell division until they reach a certain length at which they can no longer divide,' Dr Hapangama commented. 'The enzyme can extend the length of the telomeres so that they can continue to divide and this can happen in some special cells, such as sperm and egg cells, but not normally in cells that make up the organs of the body.'

'Women who have endometriosis express this enzyme in both the early and late stages of the menstrual cycle which means that the cells will continue to divide and lose their "focus" in supporting the establishment of a pregnancy,' he said. Due to this, the womb's lining 'may be more hostile to an early pregnancy', Dr Hapangama explained. 'The cells that are shed at this late stage in the menstrual cycle may be more "aggressive" and more able to survive and implant outside the uterus, causing pain in the pelvic or abdomen area.'

In general, endometriosis emerges in the lower region of the female pelvis causing extreme pain and discomfort. Around 50% of the cases involve the ovary, and the condition is also responsible for half of the infertility cases.

More than 88 million women worldwide are affected by endometriosis. While the condition affects around 15% of women of reproductive age, up to 4% of the cases are diagnosed in the postmenopausal period.

Stephanie'>http://vids.myspace.com/index.cfm?fuseaction=vids.individual&videoid=6466478">Stephanie St. James talking about Endometriosis

Wednesday, September 17, 2008

Doctors Try New Approach To Treating Endometriosis

Sep 11, 2008 6:00 pm US/Eastern
BALTIMORE (WJZ) ― A commonly used treatment for breast cancer proves successful at reducing the pain of an entirely different illness.Healthwatch reporter Kellye Lynn says local doctors are combining two drugs to ease the discomfort of endometriosis.Amy Maddox says the severe pain started when her first period arrived 22 years ago. Every month, Amy was on her back. "Intense pain where I couldn't really even function," said Maddox.An official diagnosis didn't come until Amy turned 24. She had endometriosis."I really had to go on the Internet and look it up and see what it really meant," she said."The best way to define endometriosis is to say that it is the menstrual tissue that grows outside the uterus," said Dr. Fermin Barrueto with Mercy Medical Center.It's a disorder that affects up to 10 percent of women--50 percent of premenopausal woman and more than 85 percent of women who have pelvic pain.The strongest pain medications like narcotics may take care of it for two to three hours, but the pain still comes back.Now doctors have found a way to relieve the pain with a pill. They're combining aromatase inhibitors with the endometriosis drug Lupron. "When you use the combination of these two drugs, you have a better chance," Dr. Barrueto said.

Oh man I would ask lots of questions before even considering it.
The Lupron effect can be horrible and sometimes permanant......thats what happened to me anyhow.
Best wishes to all....

Saturday, September 06, 2008

Find Out about ARD, before you have any surgery!

September is Adhesion Related Disorder Awareness Month.

What are Adhesions?
An ADHESION is a type of scar that forms an abnormal connection between two parts of the body. Adhesions can cause severe clinical problems. For example, adhesions involving the female reproductive organs (ovaries, Fallopian tubes) can and do cause infertility, dyspareunia (painful intercourse) and debilitating pelvic pain. Adhesions involving the bowel can cause bowel obstruction or blockage. Adhesions may form elsewhere such as around the heart, spine and in the hand where they lead to other problems.
Adhesions occur in response to injury of various kinds. For example, non-surgical insults such as endometriosis, infection, chemotherapy, radiation and cancer may damage tissue and initiate ADHESIONS. By far the most common kind of ADHESION is the one that forms after surgery. ADHESIONS typically occur at the site of a surgical procedure although they may also occur elsewhere.

Please visit these site for advocacy news and general education.
International Adhesion Society
Education helps prevent Adhesions!

Endo headlines

Sheesh, what ever happened to altruism.
As I scan the headlines...I feel like a widget to be profitable to corporate shareholders.

Tara's driveDanbury News Times, CT - 2 hours agoThe common wrong conclusion was that Tara had endometriosis, which occurs when endometrial tissue -- tissue normally found only in the lining of the uterus ...
Neurocrine Shares Edge Up After Promising Drug TestsSan Diego Business Journal, CA - 11 hours ago3 following positive mid-stage results for elagolix, a drug candidate aimed at treating endometriosis. Neurocrine shares, traded under the symbol NBIX on ...
Zacks Bull and Bear of the Day Highlights: Allegheny Energy ...PR-Inside.com (Pressemitteilung), Austria - Sep 5, 2008This encouraging data for the treatment of endometriosis should lead to the signing of a major partnership for pivotal trials in 2009. ...AYE - NVTL - HRB
Reunion connects now-healthy children with their medical staffLa Vista Sun, Ne - Sep 5, 2008Because of Colleen's severe endometriosis, the couple, who has lived in Papillion for five years, tried in vitro fertilization, and Colleen finally ...
High Growth Forecasted for the World Endoscopy Systems MarketMarketWatch - Sep 4, 2008... Ovarian Laparoscopy II-32 Endometriosis II-32 Tubal Ligation II-32 Vagina Creation II-33 Laparoscopic Myomectomies II-33 Ovarian Cystectomy II-33 Female ...
Androstenedione Up-Regulation of Endometrial Aromatase Expression ...Journal of Clinical Endocrinology and Metabolism, MD - Sep 4, 2008... in endometrial cells disseminated into the peritoneal cavity may enhance their survival via local estrogen synthesis, which may lead to endometriosis. ...
Extracellularly Signal-Regulated Kinase Activity in the Human ...Journal of Clinical Endocrinology and Metabolism, MD - Sep 4, 2008Context: Endometriosis is an estrogen-dependent disease characterized by the presence of endometrial tissue outside of the uterine cavity, causing pelvic ...
Neurocrine reports positive results from Phase II endometriosis trialTrading Markets (press release), CA - Sep 4, 2008The Petal study enrolled 252 patients, with a confirmed diagnosis of endometriosis, into three treatment groups - elagolix 150mg once daily, elagolix 75mg ...NBIX - OTC:CMTX

ARDvark Blog Journal of Adhesion Related Disorder: FDA:Potential Signals of Serious Risks/New Safety Information Identified by the Adverse Event Reporting System (AERS)

ARDvark Blog Journal of Adhesion Related Disorder: FDA:Potential Signals of Serious Risks/New Safety Information Identified by the Adverse Event Reporting System (AERS)