Endometriosis ~ Abdominal Pain ~ Endo ~ Scar Tissue ~ Adhesions ~ Infertility ~ Hysterectomy
Showing posts with label ovarian cyst. Show all posts
Showing posts with label ovarian cyst. Show all posts

Wednesday, April 09, 2014

UPCI/MWRI researchers to present results of immune gene profile exploring endometriosis and cancer


Published on April 7, 2014 at 8:42 AM · No Comments
Some women with endometriosis, a chronic inflammatory disease, are predisposed toovarian cancer, and a genetic screening might someday help reveal which women are most at risk, according to a University of Pittsburgh Cancer Institute (UPCI) study, in partnership with Magee-Womens Research Institute (MWRI).
Monday at the American Association for Cancer Research (AACR) Annual Meeting 2014, UPCI and MWRI researchers will present the preliminary results of the first comprehensive immune gene profile exploring endometriosis and cancer.
"A small subset of women with endometriosis go on to develop ovarian cancer, but doctors have no clinical way to predict which women," said senior author Anda Vlad, M.D., Ph.D., assistant professor of obstetrics, gynecology and reproductive sciences at MWRI. "If further studies show that the genetic pathway we uncovered is indicative of future cancer development, then doctors will know to more closely monitor certain women and perhaps take active preventative measures, such as immune therapy."

Thursday, November 10, 2011

Oxytocin receptor expression in smooth muscle cells of peritoneal endometriotic lesions and ovarian endometriotic cysts.

Oxytocin receptor expression in smooth muscle cells of peritoneal endometriotic lesions and ovarian endometriotic cysts.
Authors
Mechsner S, Bartley J, Loddenkemper C, et al.
Institution
Endometriosis Research Center Berlin, Department of Gynecology, Charité, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany.

Source
Fertil Steril 2005 Apr.:1220-31.
Abstract
To investigate the expression of oxytocin receptor (OTR) in peritoneal and ovarian endometriotic lesions.Retrospective nonrandomized study.University hospital endometriosis research center.Premenopausal women with histologically confirmed endometriosis were selected. Peritoneal endometriotic lesions (n = 120); ovarian endometriotic cysts (n = 40); peritoneal biopsies, distant from the endometriotic lesion (n = 55); and unaffected peritoneal biopsies from patients without endometriosis (n = 11) were obtained. Hysterectomy specimens from patients without endometriosis and/or adenomyosis were used for controls (n = 10).Histopathological examination of peritoneal and ovarian specimens for OTR expression and identification of smooth muscle cells by immunohistochemistry staining with antibodies against OTR and smooth muscle actin. In addition, Western blot analysis, double-immunofluorescence, and in vitro studies with primary cell cultures have been performed.Comparison of the immunoreactive score of the OTR and smooth muscle actin expression with the smooth muscle content in peritoneum with and without endometriosis.In the epithelial cells of endometriotic lesions, we could demonstrate a high OTR expression. The stromal cells were OTR negative with the exception of some single cells. By using a monoclonal anti-smooth muscle actin antibody, these cells could be identified as intrastromal OTR-positive smooth muscle cells. The peritoneum of women with endometriosis shows a significantly higher smooth muscle content than the peritoneum of women without endometriosis. There were no significant differences between the smooth muscle content of active or inactive lesions and the stage of disease.Oxytocin receptor is expressed in smooth muscle cells and epithelial cells of peritoneal endometriotic lesions and ovarian endometriotic cysts. The inhibition of OTR by specific inhibitors might be a useful approach for the treatment of endometriosis-associated pain.

Mesh
Adult
Blotting, Western
Endometrium
Female
Fluorescent Antibody Technique
Humans
Metaplasia
Middle Aged
Myocytes, Smooth Muscle
Myometrium
Ovarian Cysts
Peritoneum
Receptors, Oxytocin

Language
eng

Pub Type(s)
Journal Article Research Support, Non-U.S. Gov't

PubMed ID
15831296
http://www.unboundmedicine.com/anesthesia/ub/citation/15831296/Oxytocin_receptor_expression_in_smooth_muscle_cells_of_peritoneal_endometriotic_lesions_and_ovarian_endometriotic_cysts_

Friday, October 14, 2011

Ovarian cyst

An ovarian cyst is any collection of fluid, surrounded by a very thin wall, within an ovary. Any ovarian follicle that is larger than about two centimeters is termed an ovarian cyst. An ovarian cyst can be as small as a pea, or larger than an orange.

Most ovarian cysts are functional in nature and harmless (benign).[1] In the US, ovarian cysts are found in nearly all premenopausal women, and in up to 14.8% of postmenopausal women.[citation needed]

Ovarian cysts affect women of all ages. They occur most often, however, during a woman's childbearing years.

Some ovarian cysts cause problems, such as bleeding and pain. Surgery may be required to remove cysts larger than 5 centimeters in diameter.



Classification[edit] Non-functional cystsThere are several other conditions affecting the ovary that are described as types of cysts, but are not usually grouped with the functional cysts. (Some of these are more commonly or more properly known by other names.) These include:

Dermoid cyst
Chocolate cyst of ovary: An endometrioma, endometrioid cyst, endometrial cyst, or chocolate cyst is caused by endometriosis, and formed when a tiny patch of endometrial tissue (the mucous membrane that makes up the inner layer of the uterine wall) bleeds, sloughs off, becomes transplanted, and grows and enlarges inside the ovaries.
A polycystic-appearing ovary is diagnosed based on its enlarged size — usually twice normal —with small cysts present around the outside of the ovary. It can be found in "normal" women, and in women with endocrine disorders. An ultrasound is used to view the ovary in diagnosing the condition. Polycystic-appearing ovary is different from the polycystic ovarian syndrome, which includes other symptoms in addition to the presence of ovarian cysts.
Ovarian serous cystadenoma
Ovarian mucinous cystadenoma
[edit] Signs and symptomsSome or all of the following symptoms[2] [3] [4] [5] [6] may be present, though it is possible not to experience any symptoms:

Dull aching, or severe, sudden, and sharp pain or discomfort in the lower abdomen (one or both sides), pelvis, vagina, lower back, or thighs; pain may be constant or intermittent—this is the most common symptom
Fullness, heaviness, pressure, swelling, or bloating in the abdomen
Breast tenderness
Pain during or shortly after beginning or end of menstrual period.
Irregular periods, or abnormal uterine bleeding or spotting
Change in frequency or ease of urination (such as inability to fully empty the bladder), or difficulty with bowel movements due to pressure on adjacent pelvic anatomy
Weight gain
Nausea or vomiting
Fatigue
Infertility
Increased level of hair growth
Increased facial hair or body hair
Headaches
Strange pains in ribs, which feel muscular
Bloating
Strange nodules that feel like bruises under the layer of skin
[edit] Diagnosis
A 2cm left ovarian cyst as seen on ultrasound
An Axial CT demonstrating a large hemorrhagic ovarian cyst. The cyst is delineated by the yellow bars with blood seen anteriorly.
A CT scan showing a 8.5 cm cyst in a 29 year old female.Ovarian cysts are usually diagnosed by either ultrasound or CT scan.

[edit] TreatmentAbout 95% of ovarian cysts are benign, meaning they are not cancerous.[7]

Treatment for cysts depends on the size of the cyst and symptoms.

Pain caused by ovarian cysts may be treated with:

pain relievers, including acetaminophen/paracetamol (Tylenol), nonsteroidal anti-inflammatory drugs such as ibuprofen (Motrin, Advil), or narcotic pain medicine (by prescription) may help reduce pelvic pain.[8] NSAIDs usually work best when taken at the first signs of the pain.
a warm bath, or heating pad, or hot water bottle applied to the lower abdomen near the ovaries can relax tense muscles and relieve cramping, lessen discomfort, and stimulate circulation and healing in the ovaries.[9] Bags of ice covered with towels can be used alternately as cold treatments to increase local circulation.[10]
combined methods of hormonal contraception such as the combined oral contraceptive pill – the hormones in the pills may regulate the menstrual cycle, prevent the formation of follicles that can turn into cysts, and possibly shrink an existing cyst. (American College of Obstetricians and Gynecologists, 1999c; Mayo Clinic, 2002e)[8]
Also, limiting strenuous activity may reduce the risk of cyst rupture or torsion.

Cysts that persist beyond two or three menstrual cycles, or occur in post-menopausal women, may indicate more serious disease and should be investigated through ultrasonography and laparoscopy, especially in cases where family members have had ovarian cancer. Such cysts may require surgical biopsy. Additionally, a blood test may be taken before surgery to check for elevated CA-125, a tumor marker, which is often found in increased levels in ovarian cancer, although it can also be elevated by other conditions resulting in a large number of false positives.[11]

For more serious cases where cysts are large and persisting, doctors may suggest surgery. Some surgeries can be performed to successfully remove the cyst(s) without hurting the ovaries, while others may require removal of one or both ovaries.[12][13]

[edit] References1.^ "Ovarian Cysts Causes, Symptoms, Diagnosis, and Treatment". eMedicineHealth.com. http://www.emedicinehealth.com/ovarian_cysts/article_em.htm .
2.^ "Ovarian cysts: Symptoms". MayoClinic.com. http://www.mayoclinic.com/health/ovarian-cysts/DS00129/DSECTION=2 .
3.^ [1]
4.^ "Ovarian Cysts Causes, Symptoms, Diagnosis, and Treatment". eMedicineHealth.com . http://www.emedicinehealth.com/ovarian_cysts/page3_em.htm .
5.^ "Ovarian Cysts – Symptoms, Treatment and Prevention". HealthScout. http://www.healthscout.com/ency/1/725/main.html#SymptomsofOvarianCysts .
6.^ "Ovarian Cysts". http://www.medicineonline.com/topics/O/2/Ovarian-Cysts.html .
7.^ http://www.nhs.uk/Conditions/Ovarian-cyst/Pages/Symptoms.aspx
8.^ a b "Ovarian Cysts Treatment & Monitoring". Medicine Online. http://www.medicineonline.com/topics/O/2/Ovarian-Cysts/info/Treatment-&-Monitoring.html .
9.^ [2]
10.^ [3]
11.^ MedlinePlus Encyclopedia CA-125
12.^ "HealthHints: Gynecologic Health (January/February, 2003)". Texas AgriLife Extension Service: HealthHints. http://fcs.tamu.edu/health/health_education_rural_outreach/Health_Hints/2003/jan-feb/gynecologic_health.php .
13.^ http://ovariancystinfo.weebly.com/  Cyst on Ovary
[edit] External links"Ovarian cyst Introduction". Health encyclopaedia – NHS Direct. http://www.nhs.uk/conditions/Ovarian-cyst/Pages/Introduction.aspx. Retrieved 3 May 2011.
David B. Redwine, MD. "Endometriosis Persisting after Removal of the Uterus, Ovaries and Fallopian Tubes, Removing Disease, Not Organs, Key to Long-Term Relief". http://www.endometriosistreatment.org/html/reprint7.html . Retrieved 23 February 2009.
"Hemorrhagic Ovarian Cyst". http://www.hemorrhagicovariancyst.com/.

"Corpus Luteum Cyst". http://donorivf.org/articles/corpus-luteum-cyst/.

"Ovarian cyst symptoms". http://www.ovariancystreatment.com/category/ovarian-cyst-symptoms/.
http://en.wikipedia.org/wiki/Ovarian_cyst