Endometriosis ~ Abdominal Pain ~ Endo ~ Scar Tissue ~ Adhesions ~ Infertility ~ Hysterectomy
Showing posts with label Lupron. Show all posts
Showing posts with label Lupron. Show all posts

Friday, May 02, 2014

Dr. Drew doesn’t understand your “garbage” diagnosis ~ Endometriosis and Interstitial Cystitis

Grrrrrrrrrr. All the work we do for awareness and then this schmuck comes along...

The "Loveline" cohost draws outrage for his comments on endometriosis



Dr. Drew Pinsky is a board certified internist and assistant clinical professor of psychiatry at USC, but most of us know him better as radio and cable television’s most tireless ambulance chaser. Over the years, he’s doled out a variety of less than sound and/or helpful ideas. But when he speculated recently to a “Loveline” caller about his fiancée’s endometriosis, he definitively made the case against getting medical advice from flippant talk show hosts.
As Erin Gloria Ryan first noted on Jezebel, Pinsky was fielding a call from a man who was concerned about his girlfriend’s “multitude of conditions,” including endometriosis, interstitial cystitis, lactose intolerance and what he described as “no stomach lining.” The good doctor quickly interjected before the listener could even pose his question, explaining, “These are what we call sort of functional disorders. Everything you mentioned, everything you mentioned, are things that actually aren’t discernibly pathological. They’re what we call ‘garbage bag diagnoses,’ when you can’t think of anything else, you go, ‘Eh, it’s that.’ So, it then makes me question why is she so somatically preoccupied that she’s visiting doctors all the time with pains and urinary symptoms and pelvic symptoms, and then that makes me wonder, was she sexually abused growing up?”
Though the caller did acknowledge that his fiancée had in fact survived abuse, let’s take a step back here and observe that he never said the woman was “preoccupied” and “visiting doctors all the time” – on the contrary, he said she almost always “refuses” to go to doctors, even when she’s “in so much pain.” But Dr. Drew had a handy explanation, stating, “Trust me, she saw lots of doctors before you.” He then went on to explain why her early abuse was causing her problems now. “When people have unexplained pain, pelvic pain, it’s called somatoform dissociation,” he said, “and the only way her body, which was suffering during those early experiences, can tell its tale of woe is with pain. And she really needs to see a trauma specialist, not a urologist. Know what I’m saying?” This was immediately segued with Pinksy’s colleague joking that an additional way someone could have unexplained pelvic pain was by having sex with the show’s guest, Alan Thicke. Charming.
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
Here is the link to the CNN contact form for Dr. Drew's show...also what I wrote. Please give them a piece of your mind. IC folks....go get him!
Dr Drews comments on endometriosis are outrageous. He is not educated in a disease that strikes more than one in ten women! Find another doctor! Chronic stage 4 endo with severe adhesions has almost killed me twice. It is real, incurable and I hope you devote air some time in spreading awareness about endometriosis to counteract  the sad stereotype that has made the burden of this horrible disease even harder. 


Sunday, April 06, 2014

Lupron Side Effects ~ Tell you Lupron Story on Erin Brockovich Site ~ Read others stories

Lupron Side Effects

For far too long now, I have been contacted by people who tell me that they have been adversely impacted by Lupron. In fact, since 1999, the FDA has received adverse drug reports about Lupron from in excess of 4,000 women and approximately, 3,000 men. According to the FDA, in 325 of those cases, hospitilization was necessary and 25 women died, directly related to Lupron use.
The shared stories on this site reveal lives that have been irreparably damaged. We need to do something about this. Nothing is more powerful in coercing change than the voices of the people. I hope that this site is a place where you can come and share your story and thoughts. This is a place where you can link to other Facebook groups, read blogs and learn about what rights you may have and current news on the Lupron. This is a place where we can become stronger together.
- See more at: http://www.lupronsideeffects.net/#sthash.BMD1RGV9.dpuf

http://www.lupronsideeffects.net/

Saturday, March 15, 2014

How can diagnosis for endometriosis be improved?

Wednesday 12 March 2014 - 8am PST
"Let's start with the gynecologists," begins Linda Griffith.
"Many of them trained in a day when the classic endocrinology and gynecology textbooks described endometriosis as follows: 'The typical endometriosis patient is a nulliparous white woman in her 30s who is well-educated and tends to be highly anxious.' Yup, that is the profile of the patient with the persistence and resources to get diagnosed prior to the 1990s."
Medical News Today is speaking to Massachusetts Institute of Technology (MIT) biological engineer Linda Griffith on the eve of Endometriosis Awareness Day, which will be marked by a huge peaceful demonstration.
An international "Million Women March" will take place on Thursday, March 13th. It begins in Washington, DC, but involves participants in 53 countries across the world."

Sunday, December 22, 2013

Why does my hip hurt so bad?

Ok this is plausible...but what doc can I convince OR is it from that evil lupron..eating my bones away?

2012  
Japanese journal of radiology
  
  
  
  
  
  
We report the case of a young woman with recurrent unilateral hip pain. A polylobular cystic mass was found in the right adductor space. Magnetic resonance imaging (MRI) revealed a polynodular mass migrating from the intrapelvic region along the obturator nerve. Because of a history of cyclic pain and the characteristics on MRI (hypointense rim and spots of spontaneous hyperintense signal on T1-weighted images), an endometrioma was suspected. The diagnosis of endometriosis was later confirmed through ultrasound-guided biopsy.
(Waer et al. 2012)
Waer P, Samson I, et al. (2012). Perineural spread of endometriosis along the obturator nerve into the adductor thigh compartment. Jpn J Radiol 30 (5): 446-9.
PMID: 22350637  DOI: 10.1007/s11604-01

http://www.torna.do/s/Perineural-spread-of-endometriosis-along-the-obturator-nerve-into-the-adductor-thigh-compartment/?x=5&y=1

Thursday, November 17, 2011

Endometriosis slowly emerges as a debilitating Disease for Women

Endometriosis slowly emerges as a debilitating Disease for Women
PDF | Print | E-mail

Written by Cleophas Mutinda




Imagine a pain in your abdomen so excruciating that you are unable to get out of bed for several days every month. That is horrible enough, but when it continues 12 times a year for more than 27 years, majority of people would agree it is cruel.

Most women with endometriosis will recognise this shocking scenario as not imaginary, but very real. They know the misery of pelvic pain and have poignant stories of how endometriosis has devastated their lives with terrible suffering. Many women feel angry or despondent about being robbed off a normal life during teenage, adulthood and even sometime a ruined motherhood.

Endometriosis is a gynaecological condition, which occurs when, cells like the ones (endometrial cells) lining inside of the uterus (womb) grow outside, usually on the surfaces of organs in pelvic and abdominal areas. It can be found within the peritoneal cavity, on the ovaries and the bowels or bladder. In extremely rare cases, endometriosis can be found in lungs or other parts of the body. Endometriosis can affect any menstruating woman, from time of her first period to menopause, regardless of race, ethnicity or socio-economic status. Endometriosis rarely persists after menopause. The disorder, for which there is no absolute cure, affects over 70 million women and girls worldwide. Often stigmatized as simply “painful periods,” Endometriosis is a puzzling and widely misunderstood illness.

It is not known exactly what causes endometriosis. But over the years several theories have been advanced to explain the probable cause of the disease although none can fully explain the various clinical manifestations of the disease. A theory proposed by John Sampson in the 1920s, suggests that endometriosis may result from something called “retrograde menstrual flow”, in which some of the tissue that a woman sheds during her period flows back through the tubes and grows in the pelvic cavity. While studies show that retrograde menstrual flow is a universal phenomenon among women of reproductive age, the theory fall short of explaining why the tissues survive in some women, but fail in others. Another theory proposed by Iwanoff in 1898, claims that, the transformation of what we call coelomic epithelium into endometrial-like tissue may be a cause of endometriosis. This theory has been supported by experimental data. The induction theory, proposes that an endogenous factor can induce peritoneal cells to develop into endometrial tissue. This theory has been supported by experiments in rabbits.



Lymphatic or vascular hypothesis suggests that endometrial fragments may be transported through blood vessels or the lymphatic system to other parts of the body. This theory speculates how endometriosis ends up in distant sites, such as the lung, brain, or the skin. A genetic linkage has been adduced which claims that, this disease could be inherited, or result from genetic errors, making some women more prone to develop the condition than others.



Studies show that the risk of endometriosis is seven times greater if the disease has affected a first-degree relative. This theory has been supported by experiments in mouse model but has not been verified either in women. Immunological etiology (cause) has also been conjured since studies report that many women with endometriosis exhibit immunological abnormalities. It is speculated that the immune system may fail to clear the menstrual debris in the pelvic cavity, allowing the endometrial cells to implant and develop into endometriosis.



Also most scientists agree that endometriosis is exacerbated by oestrogen; a hormone involved in the thickening of the endometrium and appears to promote the growth of disease implants. Some studies have pointed out environmental factors like toxins may contribute to the development of endometriosis, though this theory has not been confirmed and remains controversial.



The most common symptoms of endometriosis are abdominal pain and infertility. Some studies have reported that endometriosis may occur in 30%-40% of women with infertility and the incidence of endometriosis in women with pelvic pain may be higher than 50%.



Endometriosis associated pain may include but not limited to extremely painful (disabling) menstrual cramps, chronic pelvic pain (which includes lower back pain and pelvic pain), pain during or after sex, painful bowel movements or painful urination during menstrual periods, heavy menstrual periods and bleeding between periods. The amount of pain a women feels is sometimes not linked to degree of endometriosis. Some women have no pain even though their disease is extensive, while others have severe chronic pelvic pain even though they have only few affected areas.

The relation between endometriosis and pain is still shrouded in the mist of intricate puzzle and ignorance. Many women with endometriosis feel pain during their periods. Normally, a woman’s menstrual cycle involves her endometrial tissue to build up, breaks down into blood and tissue debris, and is shed as her menstrual flow or period. This cycle of growth and shedding happens every month under normal condition. Endometriosis grows outside the uterus and also goes through a similar cycle, build-up, breakdown and bleed every month. The problem is the tissue is in the wrong place and can’t leave the body the way a woman’s period normally does. Studies show that as part of this process, endometriosis may spur the production of substances that may irritate the nearby tissue, as well as provoke the release of chemicals that cause or mediate pain. Over time, endometriosis areas can grow and become nodules or bumps on the surface of pelvic organs, or become cysts (fluid-filled sacs) in the ovaries and may cause the organs in the pelvic area to adhere together.

Endometriosis is more than just simple "killer" cramps. Women and girls around the world continue to suffer in silence with a disease that can be potentially devastating to every aspect of their lives. It can be so painful as to render a woman or teenager unable to care for herself or her family, attend work, school, or social functions, or go about her normal routine. Endometriosis has a negative impact on the individual quality of life, affecting both physical and emotional well-being. A study by the American Endometriosis Association, demonstrated that 81% of the endometriosis patients in USA were unable to work, including household chores, because of pelvic pain. Approximately 27% were incapacitated for 3 or more days and 87% complained of fatigue or low energy. These figures are indicators of enormous suffering, in addition to the healthcare costs incurred. The need to develop intervention strategies is eminent, a published poll reveals women have to wait an average of 11.7 years in US and 8 years in UK to get a correct diagnosis after the initial onset of symptoms and a patient will seek the counsel of five or more physicians before her pain is adequately addressed and diagnosed. Once diagnosed, it is not unusual for a patient to undergo repeat surgeries and embark on many different medical therapies in an attempt to treat her symptoms. Endometriosis is a bit puzzling. We do not know why it causes such extreme symptoms in some women, while less in others. The treatment options can sometimes be unsuccessful. Sadly, endometriosis is associated with menstruation, sex, infertility, and pain (taboos in many societies), thus it is a disease that is not well known, understood, or accepted in the general public. This is frustrating for those who suffer from endometriosis, and for those who care for someone with the disease.

There is no non-invasive test to diagnose endometriosis. In fact, the only gold standard diagnosis of endometriosis is a surgical procedure known as laparoscopy and confirm histologically by taking a biopsy of the suspicious tissue.

However, this is an expensive, minimally invasive procedure. Furthermore, a specialised surgeon is needed for adequate assessment of the pelvis, for recognition of the various types and appearances of the disease. If the patients decline surgery, this makes diagnosis a challenge, and therefore an experienced gynaecologist should be able to recognise symptoms suggestive of endometriosis. The fact that there is no non-invasive diagnostic test for endometriosis is frustrating for clinicians as well as for women with the disease and underscores the need for search of better diagnostic tools.

Since the cause of endometriosis remains unknown, a treatment that fully cures the disease is yet to be developed. Choosing a holistic, treatment option comes down to the individual woman's needs, depending on symptoms, age, and reproductive desires.

Pain is the most common symptom in many women with endometriosis, mainly managed by painkillers, which may vary from simple analgesics to non-steroidal anti-inflammatory drugs. Most researchers agree that endometriosis is exacerbated by oestrogen. Subsequently, hormonal treatments for endometriosis attempt to reverse oestrogen production in a woman's body and thereby alleviate symptoms. However, hormonal therapies have varying degrees of side effects, and unfortunately, whatever pain relief is achieved tends to be only temporary for many women. Most gynaecologists agree that laparoscopic surgery is the only way to diagnose and treat endometriosis. Laparoscopy involves a small cut or incision in the abdomen, inflating the abdomen with harmless gas, and then inserts a viewing instrument with help of light (Laparoscope) into the abdomen. The success of surgery depends largely on the skills of the surgeon and the thoroughness of the surgery. The aim is to remove all endometriosis lesions, cysts, and adhesions. Today, most endometriosis surgery is being done through the laparoscopy, although a full abdominal incision called a laparotomy may still be required in rare cases for extensive disease or bowel resections.

Although the prevalence of endometriosis is well documented in women living in the developed world, studies among African women are still limited. The current myth is that endometriosis rarely affects women of African origin. However, among African-American women in the USA, studies have shown endometriosis is one of the common indications for major gynaecological surgery and hysterectomy, and is associated with a high hospital costs. Although genetically, African-American and African women from the African continent are not necessarily identical given the known genetic admixture among the African-American population. Lack of awareness of endometriosis as a potentially disabling disease and poor access to state-of art diagnostic and therapeutic facilities has contributed to the meagre data on prevalence of the disease in the African population. There is need to initiate awareness campaign of endometriosis to reach all women in Africa. Also to highlight the general lack of information, facilitate endometriosis research efforts and draw attention to the impact and implications of the disease to healthcare systems in our country and the continent in general.

The writer is a Senior Scientist with special interest in endometriosis and ovarian cancer research

http://www.africasciencenews.org/en/index.php/health/63-health/194-endometriosis-slowly-emerges-as-a-life-threatening-disease-for-women

Friday, November 04, 2011

Massachusetts Adopts Groundbreaking Endometriosis Resolution

http://www.prweb.com/releases/2005/11/prweb306562.htm
Representative Elizabeth A. Poirier (R) introduces Endometriosis Awareness to Massachusetts with the resolution below urging increased awareness of endometriosis.
Email PDF Print .(PRWEB) November 5, 2005

Massachusetts House of Representatives

Urging Increased Awareness of Endometriosis

Whereas, Endometriosis is a painful, reproductive and immunological disease which is a leading cause of female infertility, chronic pelvic pain, and gynecological surgery, and accounts for nearly half the 600,000 hysterectomies performed annually, and endometriosis is more prevalent than Alzheimer's disease, Parkinson's disease and even Breast Cancer, that places significant costs for the individual, and the Commonwealth in medical bills and lost productivity; and

Whereas, Endometriosis can negatively affect a woman or teen's ability to work, attend school, social functions or care for herself and her family, and can frequently be misdiagnosed due to lack of awareness and understanding of the symptoms ; and

Whereas, Endometriosis symptoms include pelvic pain with or without menstruation, infertility, miscarriage, ectopic pregnancy, pain associated with sexual intercourse, gastrointestinal difficulties, fatigue, chronic pain, allergies and other immune system-related dysfunction and associations to diseases including multiple sclerosis, lupus, and fibromyalgia, and endometriosis can lead to painful internal scar tissue know as adhesions, resulting in a complex set of symptoms called Adhesion Related Disorder; and

Whereas, studies have also shown an elevated risk of certain cancers and autoimmune disorders in women with endometriosis and rarely, even malignant changes within the disease itself, thus researchers remain unsure as to the specific cause of endometriosis and there is no definitive cure, and current treatments are often accompanied by significantly negative side effects; and

Whereas, in recognition of the disabling effects endometriosis as a significant disabling disease in women, it is incumbent upon the citizens of the Commonwealth of Massachusetts to support the courageous individuals living and coping with this painful condition; therefore be it

Resolved, That the Massachusetts House of Representatives moves to promote Endometriosis Awareness Month every March and to encourage awareness of the Endometriosis Research Center, The Endometriosis Association, and The International Adhesion Society; and be it

Resolved, That a copy of these resolutions be forwarded by the clerk of the House of Representatives to the Endometriosis Association.

House of Representatives, adopted October 31, 2005

http://www.endometriosisassn.org/
http://www.endocenter.org/
http://www.adhesions.org/
http://endotimes.blogspot.com/

Our deepest gratitude to Representative Elizabeth A. Poirier for her continuing dedication to women's issues in the Commonwealth.

Sunday, August 21, 2011

Combating endometriosis

A new surgical procedure offers hope and promise
Vasudha Rai

Ashwini K. Trehan, consultant gynaecological surgeon at Spire Elland Hospital and Dewsbury and District Hospital, UK, is giving many with endometriosis a reason to smile.

While pelvic peritoneal excision surgery (basic laparoscopy where parts affected with endometriosis are removed) is effective, it has a 50% recurrence rate and may result in the removal of ovaries. Dr Trehan’s technique is called total pelvic peritoneal excision, where the entire pelvic lining is removed to prevent recurrence.


In a study conducted by Dr Trehan and F. Sanaullah, post-CCT clinical fellow in minimal access surgery, and C. Rooke, clinical audit facilitator, at Dewsbury and District Hospital in 2008, it was found that the new surgery improved the symptoms of endometriosis in 89.6% of women.

The circumstances in which removing the entire pelvic lining may not work is when the disease has spread into the uterus or in spots where endometriosis has reached very deep into the organs.

Dr Trehan says ovarian removal is the main reason for early death in women because it increases the risk of cancer, heart disease and acute menopause.


For more information, visit www.endometriosis-consultant.co.uk



Friday, August 19, 2011

New hope for endometriosis sufferers

By Cheah Ui-Hoon

Women who suffer from endometriosis now have another drug to turn to in their struggle to manage the condition. A new pill, Visanne, has been designed to tackle the problem differently from conventional hormonal medicine. Whereas the latter prevents the ovaries from producing estrogen - and gives women menopausal side effects as a result - the new drug does not block the production of estrogen.

'This new medicine takes a completely different approach. It blocks ovulation, thus lowering the chances of endometriosis, but it does not block estrogen,' explains Thomas Strowitzki, director of the Department of Gynaecological Endocrinology and Reproductive Medicine at the University of Heidelberg, Germany.

Conventional GnRH (Gonadotropin-Releasing Hormone) analogue drugs put women in a menopausal state for the duration of the treatment. They block the pituitary gland, which stops estrogen production, thus relieving the pain associated with endometriosis. Women are put on this treatment for up to a maximum 12-month course.

Side effects from the resulting low levels of estrogen, however, are common, and most women will experience at least one or two symptoms commonly associated with the menopause. These include insomnia, headaches, mood swings, acne, dizziness, depression, decreased libido and vaginal dryness, although they usually disappear soon after conventional GnRH treatment ends.

Endometriosis is a condition in which the cells of the womb lining (the endometrium) are found outside the womb, usually in the pelvis and around the womb, ovaries and fallopian tubes. Unlike endometrial cells that are normally found in the uterus and which are shed during menstruation, those that grow outside the uterus remain in place and are stimulated during each menstrual cycle. Over the long term, this process gives rise to pain and can also result in scars or lesions on the tubes, ovaries, and surrounding structures in the pelvis.

Left undiagnosed or untreated, endometriosis can be a frustrating condition. Painful periods can cause a woman to miss work or school, strain sexual relationships, and affect the overall quality of her life. Besides irregular bleeding, endometriosis can also be a cause of infertility.

Dr Strowitzki says that doctors don't know why 15 per cent of fertile women develop endometriosis. 'To be honest, we don't know the risk factors and we don't know which group of women is at risk. We also don't know how to avoid the disease as it's not like cancer,' he adds.


Thursday, July 28, 2011

Rectal endometriosis causing colonic obstruction and concurrent endometriosis of the appendix: a case report


Introduction Endometriosis is a clinical entity which presents with functioning endometrial tissue at sites outside the uterus. Bowel endometriosis is usually asymptomatic, but it may show non-specific symptoms.

The presence and/or association of appendiceal endometriosis, concomitant with rectal endometriosis, is possible.Case presentationA 36-year-old Greek woman was admitted to the emergency room of our hospital with signs of acute abdomen. On physical examination, our patient had a painful distended abdomen.

Digital examination revealed an empty rectum and bowel obstruction was diagnosed. Our patient underwent exploratory laparotomy and rectum stenosis (almost complete obstruction) was observed.

The bowel stenosis was resected, and temporary colostomy and appendectomy were performed. The pathology report showed endometriosis of the colon and the appendix, and our patient received medical treatment for endometriosis.

Six months after this operation our patient had another surgery for restoration of large bowel continuity. No endometriosis was found.

Our patient was doing well at the one-year follow up.

Conclusion: Endometriosis of the bowel is a disease that may cause large bowel obstruction. In women of reproductive age, the surgeon should consider endometriosis as a differential diagnosis in case of various gastrointestinal symptoms.

Author: N. KatsikogiannisA. TsarouchaK. DimakisE. SivridisC. Simopoulos
Credits/Source: Journal of Medical Case Reports 2011, 5:320

Endotimes blogger opinion: Yikes, I would never have an open surgery....if they can't do it laparoscoply then they aint good enough!

Monday, May 09, 2011

ENDURING Endometriosis

Painful disorder may increase risk of infertility

EILEEN CIPRIANI Times Leader Correspondent


It is among the top three causes of infertility and pelvic pain in women. There is a research center and a foundation in the United States, as well as an international society and yellow ribbon devoted to the disorder. According to the U.S. Department of Health and Human Services more than 5 million women in America alone have been diagnosed. Oscar Award-winning actress Susan Sarandon and “Top Chef” host Padma Lakshmi are among them. In March at the 3rd annual Blossom Ball fundraiser for research in New York, Sarandon and Lakshmi shared their first-hand experiences with the malady -- endometriosis.

Endometriosis is when endometrial cells that normally line the interior of the uterus relocate in other areas of the body. The cells usually become displaced in the pelvic area, but in extremely rare cases they can be found in other parts of the body, says Dr. Jennifer Sue Gell of Geisinger Health System’s Women’s Health Center. Gell is obstetrics-gynecology certified with a practicing specialty in reproductive endocrinology and fertility.


In endometriosis the displaced tissues acts as it normally would during the menstrual cycle. It thickens and bleeds, but because it is unable to exit the body it irritates surrounding tissue causing pain and eventually develops scar tissue and adhesions.

Click link to read the rest
http://www.timesleader.com/features/ENDURING_Endometriosis_05-02-2011.html

Sunday, April 24, 2011

Eggsploitation

04-06-11: Award-winning documentary, 'Eggsploitation', was shown at Boston College Law School. Risks of lupron, and the lack of data-tracking of women who undergo egg donation and IVF, were discussed. 'RESOLVE' (the organization that alleges to "educate, advocate, and support the infertile") had in attendance a Board Member who attempted to discredit 'Eggsploitation' as "biased" and 'not representative of the industry'. 'RESOLVE's' Board Member failed to inform the audience of 'RESOLVE's' conflicts of interest: RESOLVE has a history of receiving hundreds of thousands of dollars from the fertility drug manufacturers, fertility clinics, and fertility doctors.

From: http://www.lupronvictimshub.com/

Global Endometriosis Market to Reach $1.3 Billion by 2017, According to a New Report by Global Industry Analysts, Inc.

Monday, April 4, 2011

San Jose, CA (Vocus/PRWEB) April 04, 2011

Endometriosis is the most common health problem among women. As per the estimates of World Endometriosis Research Foundation, an estimated 170 million women suffer from endometriosis globally. Endometriosis-related healthcare costs and productivity losses exceed US$4,000 per patient annually. Annual direct and indirect endometriosis-related costs are estimated to cross US$20 to US$25 billion in the US over the coming years. The disease affects reproductive age women more compared to post-menopausal women. Endometriosis affects more than 90 million women of reproductive age globally. The disease represents one of the major causes of female infertility and constitutes for about 30% of infertility cases in women. More than 7.8 million women in the US suffer from endometriosis-related symptoms, which include chronic pelvic pain, dysmenorrhea, and infertility.

Gonadotropin-Releasing Hormone GnRH agonists, Progestins, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), and contraceptives are the major therapeutic options available for the treatment of endometriosis. The present drugs are characterized by safety and efficacy concerns. Huge unmet medical need exists for novel medication with improved safety profile and minimal side effects. Lupron Depot from Abbott Laboratories, Depo-Provera and Synarel from Pfizer, are the major drugs approved for the treatment of endometriosis. Abbott's Lupron (Leuprolide) represents one of the leading drugs for the treatment of endometriosis.

The global endometriosis market is led by the US, as stated by a new market research report on Endometriosis. Europe represents the next largest region, while growth is expected to emanate mainly from the 'Rest of the world' market, which is expected to depict a compounded annualized growth of more than 6.0% during 2009-2017. The future looks promising for endometriosis, with increasing efforts being made in research, and novel treatment emerging in the field of surgical as well as pharmaceutical treatment. In addition, myths are being dispelled regarding the disease, and alternative methods are being readily accepted. Non-invasive diagnostics, including next-generation MRIs, are forecast to become major tools for the diagnosis of endometriosis, although laparoscopy, an invasive surgery, still remains the gold standard for performing disease diagnosis. Genetic and biomolecular diagnostic tests are also being trailed.

Drugs that are expected to drive future market growth include Abarelix, SERMs (Selective Estrogen Receptor Modulators), Extracellular Matrix Modulators, Terbutaline, and RU-486. Abarelix, for instance, is a GnRH antagonist, presently undergoing clinical trials in the US for its use in endometriosis. The emergence of certain other promising innovative drugs, including Repros Therapeutics' Proellex, Neurocrine's Elagolix, and Bayer HealthCare Pharmaceuticals' Visanne (Dienogest) is forecast to have a robust impact on the endometriosis market in future. Elagolix is the first oral non-peptide gonadotropin-releasing hormone (GnRH) antagonist. Meanwhile, Proellex acts by selectively blocking the activity of progesterone, and allows the secretions of tonic hormone by alleviating the negative side effects of GnRHa. Besides pipeline drugs, Angiogenesis therapy is forecast to be one of the key potential treatment options for endometriosis, whether used alone or as an adjunct therapy. Angiogenesis theory holds that endometriosis lesions could be destroyed by cutting off the blood supply.

Major players profiled in the report include Abbott Laboratories, AEterna Zentaris Inc., AstraZeneca Plc., Bayer HealthCare Pharmaceuticals Inc., Eli Lilly and Company, Meditrina Pharmaceuticals Inc., Neurocrine Biosciences Inc., Paladin Labs Inc., Pfizer Inc., Repros Therapeutics Inc., among others.

The research report titled "Endometriosis: A Global Strategic Business Report" announced by Global Industry Analysts Inc., provides a comprehensive review of endometriosis, current market trends, key growth drivers, the available treatment, overview of major drugs, insight into current leading and pipeline drugs, recent product approvals, recent industry activity, and profiles of major/niche global as well as regional market participants. The report provides annual sales estimates and projections for Endometriosis treatment for the years 2009 through 2017 for the following geographic markets - US, Canada, Japan, Europe, and Rest of World. Also, a six-year (2003-2008) historic analysis is provided for additional perspective.

For more details about this comprehensive market research report, please visit - www.strategyr.com/Endometriosis_Market_Report.asp
About Global Industry Analysts, Inc.
Global Industry Analysts, Inc., (GIA) is a reputed publisher of off-the-shelf market research. Founded in 1987, the company is globally recognized as one of the world's largest market research publishers. The company employs over 800 people worldwide and publishes more than 1200 full-scale research reports each year. Additionally, the company also offers thousands of smaller research products including company reports, market trend reports, and industry reports encompassing all major industries worldwide.

Global Industry Analysts, Inc.
Telephone: 408-528-9966
Fax: 408-528-9977
E-mail: press(at)StrategyR(dot)com
Web Site: www.StrategyR.com/
# # #


For the original version on PRWeb visit: www.prweb.com/releases/prwebendometriosis/laproscopy/prweb8257835.htm

http://sfgate.com/cgi-bin/article.cgi?f=/g/a/2011/04/04/prweb8257835.DTL


Tuesday, March 29, 2011

If your doctor wants you to take Lupron, please watch this news clip first!

I took a 6 months course of Lupron when I was 32. All I can seem to remember about this is I wished  I had never done it. The side effects were awful. The pain of stage 4 endometriosis and their accompanying adhesions came right back.
I am now 49 with osteoperosis and almost an inch shorter than I was my whole adult life.
One time I presented at ER Mass General....and that witch sneered at me...."why aren't you taking lupron?"
I got off the table and just kept walking.....outta there!

Please....Lupron does not cure endometriosis.

Watch this investigative report before you decide to go this course.

Saturday, March 26, 2011

'Top Chef's Padma Lakshmi gets personal about endometriosis

'I didn’t know how much pain I was in until I wasn’t in pain anymore"

Cause Celeb highlights a celebrity’s work on behalf of a specific cause. This week, we speak with model, actress and television host Padma Lakshmi about her charity, the Endometriosis Foundation of America. Lakshmi herself had the painful disorder, which affects millions of women and adolescent girls in the United States.



Lakshmi joined the organization and relaunched it with Dr. Tamer Seckin in 2009. Lakshmi, host of “Top Chef” on Bravo channel, uses her celebrity to bring awareness to the disease and its symptoms. Endometriosis is an often painful disorder in which tissue that normally lines the inside of the uterus grows outside the uterus.On March 18, the Endometriosis Foundation of America hosted its third annual Blossom Ball to raise funds to combat the debilitating condition. To find out more information about endometriosis and future events, you can visit http://www.endofound.org/.

Click here to read more



Wednesday, March 23, 2011

FDA Approves BENLYSTA® For Lupus In Breakthrough For Millions Of Sufferers

Since Lupus has an ancillary tie to endometriosis we report on such issues.
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

FDA Approves BENLYSTA® For Lupus In Breakthrough For Millions Of Sufferers-199m ago Medical News Today
The Lupus Research Institute (LRI) and its National Coalition of state and local lupus organizations welcome the U.S. Food and Drug Administration's (FDA) historic approval of BENLYSTA® (belimumab) for systemic lupus erythematosus (lupus), launching the
Click here to read the rest

Saturday, January 24, 2009

Endometriosis EndoTimes Blog

Having babies after being diagnosed with endometriosisExaminer.com - Jan 22, 2009I knew it wasn’t going to be good news because when I woke up from the surgery my doctor came in and told me that I had stage 5 endometriosis and one of the ...

lity problems and endometriosisguardian.co.uk, UK - Jan 21, 2009Doctors don't know exactly how endometriosis can reduce your chances of getting pregnant. But there are some theories. To read more about the causes and ...Surgery for endometriosis guardian.co.ukHow do doctors diagnose endometriosis? guardian.co.ukWhat's the evidence for surgery to remove endometriosis? guardian.co.ukguardian.co.uk - guardian.co.ukall 12 news articles »

Endometriosis linked to embryo defectsUnited Press International - Jan 20, 200920 (UPI) -- A US researcher links endometriosis to abnormalities resulting from defects in the early embryo. Endometriosis is a disease that can cause pain ...

What is endometriosis?guardian.co.uk, UK - Jan 21, 2009If you have endometriosis, small pieces of the lining of your womb stick to other parts of your body, such as your ovaries or your bladder. ...What are the symptoms of endometriosis? guardian.co.ukWhat will happen to me? guardian.co.ukQuestions to ask your doctor guardian.co.ukall 4 news articles »

What treatments work for endometriosis?guardian.co.uk, UK - Jan 21, 2009If you have endometriosis, the tissue that normally lines your womb grows in other places outside the womb such as your ovaries and part of your bowel. ...Hormone treatments for endometriosis guardian.co.ukHormone treatments before surgery guardian.co.ukTypes of hormone treatment guardian.co.ukguardian.co.uk - guardian.co.ukall 10 news articles »

Who's at risk of endometriosis?guardian.co.uk, UK - Jan 21, 2009Reproductive history and endometriosis among premenopausal women. Obstetrics and Gynecology. 2004; 104: 965-974. Sangi-Haghpeykar H, Poindexter AN 3rd. ...

Progress made in understanding causes and treatment of endometriosisHindu, India - Jan 17, 2009CHICAGO: Endometriosis is a poorly understood chronic disease characterized by infertility and chronic pelvic pain during intercourse. ...

A life with endometriosisHealth24.com, South Africa - Jan 19, 2009After numerous visits to a range of specialists, I was diagnosed with endometriosis. I was immensely relieved to finally attach a medical name to the beast ...

Monday, September 22, 2008

Out-of-control enzyme may trigger endometriosis

A news flash from Stephanie St. James
http://www.myspace.com/stjamesendoawareness

Out-of-control enzyme may trigger endometriosis
Scientists may be one step closer to solving the mystery behind endometriosis — what doctors say is a common health problem for women. In their latest study, scientists at the University of Liverpool in the UK have discovered what may be triggering this condition. Their findings were recently published in the journal Human Reproduction.

The telomeres enable egg cells to continue dividing
© Shutterstock


'Endometriosis occurs when cells of the inner lining of the womb are found growing outside of the uterus,' explained Dr Dharani Hapangama from the Department of Reproductive and Developmental Medicine, University of Liverpool. 'At the time of a woman's menstruation cycle these cells, called endometrial cells, are shed and can be expelled into the abdominal cavity,' he said. 'If these cells continue to live and are implanted in the pelvis and abdomen it can cause severe pain and in serious cases can lead to infertility.'

The telomerase enzyme, found in cells and the inner lining of the womb, patrols the end parts of chromosomes, called telomeres. These telomeres hold the two ends of the chromosomes together and ensure that they stay intact during cell division. The researchers found that telomerase is released by cells in the inner lining of the womb at the beginning and towards the end of the menstrual cycle in women suffering from this condition. Cancer cells also contain this enzyme, which seemingly replicates DNA sequences during cell division in chromosomes, experts say.

The lead researcher went on to say that the team found the telomere to be unusually long in women with endometriosis. 'During menstruation, telomeres normally shorten in length with each cycle of cell division until they reach a certain length at which they can no longer divide,' Dr Hapangama commented. 'The enzyme can extend the length of the telomeres so that they can continue to divide and this can happen in some special cells, such as sperm and egg cells, but not normally in cells that make up the organs of the body.'

'Women who have endometriosis express this enzyme in both the early and late stages of the menstrual cycle which means that the cells will continue to divide and lose their "focus" in supporting the establishment of a pregnancy,' he said. Due to this, the womb's lining 'may be more hostile to an early pregnancy', Dr Hapangama explained. 'The cells that are shed at this late stage in the menstrual cycle may be more "aggressive" and more able to survive and implant outside the uterus, causing pain in the pelvic or abdomen area.'

In general, endometriosis emerges in the lower region of the female pelvis causing extreme pain and discomfort. Around 50% of the cases involve the ovary, and the condition is also responsible for half of the infertility cases.

More than 88 million women worldwide are affected by endometriosis. While the condition affects around 15% of women of reproductive age, up to 4% of the cases are diagnosed in the postmenopausal period.
http://ec.europa.eu/research/headlines/news/article_08_09_18_en.html


Stephanie'>http://vids.myspace.com/index.cfm?fuseaction=vids.individual&videoid=6466478">Stephanie St. James talking about Endometriosis