YALE (US) — Researchers may have identified a genetic basis of endometriosis, a condition that causes millions of women chronic pelvic pain and infertility.
The Yale University researchers’ discovery of a new gene mutation provides hope for new screening methods.
Published in the journal EMBO Molecular Medicine, the study explored an inherited mutation located in part of the KRAS gene, which leads to abnormal endometrial growth and endometrial risk.
Click here to read entire article: http://www.futurity.org/health-medicine/gene-variant-linked-to-endometriosis/
Showing posts with label prevention. Show all posts
Showing posts with label prevention. Show all posts
Sunday, February 12, 2012
Tuesday, January 24, 2012
New test for endometriosis
New test for endometriosis
BY KATE HAGAN
20 Jan, 2012 04:00 AM
An ultrasound is just as effective as an invasive surgical procedure in diagnosing the female reproductive disorder endometriosis, a Melbourne specialist has found, in a development that could lead to more women being treated for the painful condition.
Sofie Piessens found the new technique was more than 90 per cent effective at diagnosing endometriosis, in an analysis of 100 patients she saw between 2009 and last year.
She presented her findings at the annual scientific meeting of the Royal Australian and New Zealand College of Obstetricians and Gynaecologists last month.
About 15 per cent of women have endometriosis, which can cause severe pain and damage reproductive organs, leading to infertility in up to 50 per cent of cases.
Dr Piessens said the disorder, in which the cells lining the uterus migrate to the abdomen, was usually diagnosed with a laparoscopy, an operation to inspect the pelvic organs.
''Some people will have painful periods but not endometriosis, so to do a laparoscopy on everyone who has painful periods was quite invasive,'' she said.
''A lot of women are told the pain is normal and they have to put up with it, so there can be a significant delay in diagnosis and the endometriosis can become quite severe.''
Dr Piessens, a gynaecologist who specialises in ultrasound, said doctors had previously believed that ultrasounds could not detect endometriosis.
''Now groups around the world have published data to say if you just look backwards, behind the uterus, you can diagnosis a high proportion of women who have that really bad form of endometriosis,'' she said.
''With a normal vaginal ultrasound we look right ahead at the uterus, we turn it to the side to look at the ovaries, and I would like people to just look behind the uterus as well to look for endometriosis.
''It's something people need to become aware of and my feeling is, if there is demand from referring doctors, then imaging people will lift their game and look harder.''
Dr Piessens said the result was a speedier diagnosis which provided a template for surgeons performing complex surgery to remove the lesions.
She said the ultrasound could also be used to monitor the effect of hormone medication in shrinking the lesions, potentially avoiding surgery.
One of the patients who has benefited from the new diagnostic technique is Alana Vaughan, 29, who suffered for years with painful periods.
She said her symptoms ''returned with a vengeance'' when she stopped taking the contraceptive pill a few years ago, before she was referred to Dr Piessens who diagnosed her endometriosis. After extensive surgery to remove it, Ms Vaughan said she was now thrilled to be pregnant with twins.
http://www.canberratimes.com.au/news/national/national/general/new-test-for-endometriosis/2426662.aspx?storypage=0
BY KATE HAGAN
20 Jan, 2012 04:00 AM
An ultrasound is just as effective as an invasive surgical procedure in diagnosing the female reproductive disorder endometriosis, a Melbourne specialist has found, in a development that could lead to more women being treated for the painful condition.
Sofie Piessens found the new technique was more than 90 per cent effective at diagnosing endometriosis, in an analysis of 100 patients she saw between 2009 and last year.
She presented her findings at the annual scientific meeting of the Royal Australian and New Zealand College of Obstetricians and Gynaecologists last month.
About 15 per cent of women have endometriosis, which can cause severe pain and damage reproductive organs, leading to infertility in up to 50 per cent of cases.
Dr Piessens said the disorder, in which the cells lining the uterus migrate to the abdomen, was usually diagnosed with a laparoscopy, an operation to inspect the pelvic organs.
''Some people will have painful periods but not endometriosis, so to do a laparoscopy on everyone who has painful periods was quite invasive,'' she said.
''A lot of women are told the pain is normal and they have to put up with it, so there can be a significant delay in diagnosis and the endometriosis can become quite severe.''
Dr Piessens, a gynaecologist who specialises in ultrasound, said doctors had previously believed that ultrasounds could not detect endometriosis.
''Now groups around the world have published data to say if you just look backwards, behind the uterus, you can diagnosis a high proportion of women who have that really bad form of endometriosis,'' she said.
''With a normal vaginal ultrasound we look right ahead at the uterus, we turn it to the side to look at the ovaries, and I would like people to just look behind the uterus as well to look for endometriosis.
''It's something people need to become aware of and my feeling is, if there is demand from referring doctors, then imaging people will lift their game and look harder.''
Dr Piessens said the result was a speedier diagnosis which provided a template for surgeons performing complex surgery to remove the lesions.
She said the ultrasound could also be used to monitor the effect of hormone medication in shrinking the lesions, potentially avoiding surgery.
One of the patients who has benefited from the new diagnostic technique is Alana Vaughan, 29, who suffered for years with painful periods.
She said her symptoms ''returned with a vengeance'' when she stopped taking the contraceptive pill a few years ago, before she was referred to Dr Piessens who diagnosed her endometriosis. After extensive surgery to remove it, Ms Vaughan said she was now thrilled to be pregnant with twins.
http://www.canberratimes.com.au/news/national/national/general/new-test-for-endometriosis/2426662.aspx?storypage=0
Wednesday, January 11, 2012
Baylor scientists receive $1.35 million from Ovarian Cancer Research Fund
Baylor scientists receive $1.35 million from Ovarian Cancer Research Fund
HOUSTON -- (January 9, 2012) -- Two Baylor College of Medicine researchers have received three-year grants totaling $1.35 million from the Ovarian Cancer Research Fund for studies directed toward earlier detection of ovarian cancer.
Ovarian cancer is the ninth most common cause of cancer among U.S. women and the fifth most common cause of cancer deaths in women. An estimated 22,000 will be diagnosed with the disorder this year and more than 15,000 will die of it.
"Investigating ARID1A
Over the next three years, Hawkins will research why some women with endometriosis (the growth of cells that usually line the uterus outside that organ, often on the ovary) go on to develop a kind of ovarian cancer known as endometrioid or clear cell ovarian cancer.
"Additionally, women with endometriosis-associated ovarian cancer have a better prognosis than women without endometriosis," she said.
She will look at a gene called ARID1A that may play a role in the transformation from endometriosis cells to ovarian cancer cells. How ARID1A plays a role in the formation of tumors is not yet understood, and Hawkins plans to study both benign and malignant human tissue to find mutations in ARID1A. She will work in cell cultures to determine if ARID1A leads to increased growth of cancer cells because of interaction with other cancer genes. She will create a mouse model to mimic the low levels of ARID1A and see how early tumors form as well as to study potential therapies."
Click here to read entire article: http://www.bcm.edu/news/item.cfm?newsID=5022
HOUSTON -- (January 9, 2012) -- Two Baylor College of Medicine researchers have received three-year grants totaling $1.35 million from the Ovarian Cancer Research Fund for studies directed toward earlier detection of ovarian cancer.
Ovarian cancer is the ninth most common cause of cancer among U.S. women and the fifth most common cause of cancer deaths in women. An estimated 22,000 will be diagnosed with the disorder this year and more than 15,000 will die of it.
"Investigating ARID1A
Over the next three years, Hawkins will research why some women with endometriosis (the growth of cells that usually line the uterus outside that organ, often on the ovary) go on to develop a kind of ovarian cancer known as endometrioid or clear cell ovarian cancer.
"Additionally, women with endometriosis-associated ovarian cancer have a better prognosis than women without endometriosis," she said.
She will look at a gene called ARID1A that may play a role in the transformation from endometriosis cells to ovarian cancer cells. How ARID1A plays a role in the formation of tumors is not yet understood, and Hawkins plans to study both benign and malignant human tissue to find mutations in ARID1A. She will work in cell cultures to determine if ARID1A leads to increased growth of cancer cells because of interaction with other cancer genes. She will create a mouse model to mimic the low levels of ARID1A and see how early tumors form as well as to study potential therapies."
Click here to read entire article: http://www.bcm.edu/news/item.cfm?newsID=5022
Sunday, August 21, 2011
Combating endometriosis
A new surgical procedure offers hope and promise
Vasudha Rai
Ashwini K. Trehan, consultant gynaecological surgeon at Spire Elland Hospital and Dewsbury and District Hospital, UK, is giving many with endometriosis a reason to smile.
While pelvic peritoneal excision surgery (basic laparoscopy where parts affected with endometriosis are removed) is effective, it has a 50% recurrence rate and may result in the removal of ovaries. Dr Trehan’s technique is called total pelvic peritoneal excision, where the entire pelvic lining is removed to prevent recurrence.
In a study conducted by Dr Trehan and F. Sanaullah, post-CCT clinical fellow in minimal access surgery, and C. Rooke, clinical audit facilitator, at Dewsbury and District Hospital in 2008, it was found that the new surgery improved the symptoms of endometriosis in 89.6% of women.
The circumstances in which removing the entire pelvic lining may not work is when the disease has spread into the uterus or in spots where endometriosis has reached very deep into the organs.
Dr Trehan says ovarian removal is the main reason for early death in women because it increases the risk of cancer, heart disease and acute menopause.
For more information, visit www.endometriosis-consultant.co.uk
Write to us at businessoflife@livemint.com
Sunday, March 27, 2011
Wednesday, January 28, 2009
New Principles of Adhesion Prevention Covidien Sprayshield
New Principles of Adhesion Prevention Covidien Sprayshield
Principles in the Prevention of Adhesions
An informative powerpoint presentation about the state of adhesion patients, adhesion prevention and hopes for the future.
It is easy to register to view this presentation. Minimum personal information.
It does contain graphic surgical images.
Please use this link to register from the ISGE ( www.isge.org )
http://www.surgipeer.com/sprayshield/
This is the direct link but we are unsure it will work without registration:
http://www.ja-online.com/design/covidien_articulate_interface/SS/player.html
Principles in the Prevention of Adhesions
An informative powerpoint presentation about the state of adhesion patients, adhesion prevention and hopes for the future.
It is easy to register to view this presentation. Minimum personal information.
It does contain graphic surgical images.
Please use this link to register from the ISGE ( www.isge.org )
http://www.surgipeer.com/sprayshield/
This is the direct link but we are unsure it will work without registration:
http://www.ja-online.com/design/covidien_articulate_interface/SS/player.html
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