Susan E. Lindt, StaffIntelligencer Journal
Published: Feb 08, 2007 1:21 AM EST
HERSHEY, Pa. -
A new study suggests the drug most often prescribed to treat a cause of female infertility isn't the best one for the job.
The good news is a more effective drug already is on the market, researchers say.
Hershey Medical Center researchers studied two medications used to treat women unable to conceive because of polycystic ovary syndrome. The four-year study simply attempted to determine which drug works better, or if a combination of both is most effective.
The answer is revealed in an article published today in The New England Journal of Medicine: metformin, the drug most often prescribed, was less effective, with only 15 of 208 women in the study, or 7.2 percent, conceiving and giving birth.
Another drug, clomiphene, was more effective, with 22.5 percent, or 47 of 209 women, giving birth.
A combination of both drugs was most effective, with 26.8 percent giving birth, but the slight difference between the combination and clomiphene-only groups was considered statistically insignificant.
The study's outcome surprised researchers, who say the health care industry has accepted metformin as the more effective of the two drugs.
"I was shocked to see the data," said Hershey Medical Center physician and researcher Richard S. Legro, who directed the study and is primary author of the New England Journal article. "We definitely know (clomiphene) works. This was a down-and-out group of women who had tried everything.
"I think (clomiphene) is as good as it gets. It's a rousing success."
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1 comment:
I have suffered from adenomyosis with severe cramps during and after my period. It was very painful and heavy bleeding and severe lower back pain my pain was unbearable to a point of being not able to move and a stabbing like pain on the left of my ovaries. Pain goes away when a clot comes out. But it took a while for the clot to come out. After several meetings with my gynaecologist which she suggested "Hysterectomy" but I refused I know what Hysterectomy is and how heart aching it can be then she stated that Allopathic treatment will help in pain management but it will not cure the disease. I started treatment with a drug named "endoheal 2 mg". This gave me pain relief but reduced my periods almost to no periods with numerous side effects - spotting and fluctuation in my dates. I was not mentally satisfied to bear the side effects so I came across ''Ayurvedic doctor" who started my treatment with herbs. Though I continued above drug 'endoheal 2 mg'" parallel for nine months for easy pain management. From then I continued taking the treatment. It reduced the size of my lesion but did not reduce it further after few months. And there was no relief in pain during menstruation but my Dr. Advised me to continue it during 3 months without any gap. I had noticed a quick ageing of my skin in the last 2 years. I am a smoker but for some reason I feel my quick ageing has to do with something else because I have been smoking for a long time and it's only recently that I noticed a fast decline of my skin elasticity. After then pain radiates very badly in my left leg, lower left back and left side of my vagina. The pain normally start anytime during 3, 5,6 days, but at time I had to take a painkiller for this also as it irritates whole day. Then pain disappears after fews day. My digestion was slow but Dr. Ronnie's supplements has improved it impossible situations is becoming possible miracles gradually.
I was lucky to read in the internet about a lady who was cured from Adenomyosis through Herbal Medication. I contacted Ronnie through an email address I got from a testimony shared on the internet. Without further delay I made an order, I switched over to it. I had great breakthrough, that in the first month, I was already testifying of the effective of the Herbal medication. After 3months course of taken the medicine, all symptoms were gone. It has been 1 year and four months since I became free from adenomyosis. Anyone who is not in my position would not understand what I went through, the heart break, the pain and how frustrated I was for 6 odd years. Believe me, it was hell. I am so happy; I never believed I will be this happy again in life. My story is quite lengthy, it might help you too. You may contact Dr. Ronnie to know more via his email on. ronniemd70@gmail.com
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