Environ Health Perspect. 2005 Jul ;113 (7):858-62 16002373
Serum dioxin concentrations and age at menopause.
[My paper] Brenda Eskenazi , Marcella Warner , Amy R Marks , Steven Samuels , Pier Mario Gerthoux , Paolo Vercellini , David L Olive , Larry Needham , Donald Patterson Jr , Paolo Mocarelli
2,3,7,8-Tetrachlorobenzo-p-dioxin (TCDD), a halogenated compound that binds the aryl hydrocarbon receptor, is a by-product of numerous industrial processes including waste incineration. Studies in rats and monkeys suggest that TCDD may affect ovarian function. We examined the relationship of TCDD and age at menopause in a population of women residing near Seveso, Italy, in 1976, at the time of a chemical plant explosion. We included 616 of the women who participated 20 years later in the Seveso Women's Health Study. All women were premenopausal at the time of the explosion, had TCDD levels measured in serum collected soon after the explosion, and were > or = 35 years of age at interview. Using proportional hazards modeling, we found a 6% nonsignificant increase in risk of early menopause with a 10-fold increase in serum TCDD. When TCDD levels were categorized, compared with women in the lowest quintile (< p =" 0.77)," p =" 0.14)," p =" 0.10),"> 118 ppt) had an HR of 1.1 (p = 0.82) for risk of earlier menopause. The trend toward earlier menopause across the first four quintiles is statistically significant (p = 0.04). These results suggest a nonmonotonic dose-related association with increasing risk of earlier menopause up to about 100 ppt TCDD, but not above.
Mesh-terms: Adolescent; Adult; Age Factors; Chemical Industry; Child; Child, Preschool; Dose-Response Relationship, Drug; Environmental Pollutants, blood; Explosions; Female; Humans; Infant; Italy, epidemiology; Menopause, Premature, blood; Middle Aged; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Retrospective Studies; Tetrachlorodibenzodioxin, blood;