Thursday, April 24, 2014
Genetic Screening For Endometriosis-Associated Ovarian Cancer
April Flowers for redOrbit.com – Your Universe Online
Endometriosis is a chronic inflammatory disease that affects more than 176 million women and girls worldwide, according to the Endometriosis Foundation of America. Despite being one of the most common gynecological disorders, there is no definitive consensus on the cause of endometriosis. To add insult to injury, some women who have endometriosis are also predisposed to ovarian cancer.
A new study from the University of Pittsburgh Cancer Institute (UPCI) and Magee-Womens Research Institute (MWRI) reveals that genetic screening could someday help clinicians to know which women are most at risk.
The research team will present their results on the first comprehensive immune gene profile exploring endometriosis and cancer on Monday at the American Association for Cancer Research (AACR) Annual Meeting 2014.
“A small subset of women with endometriosis go on to develop ovarian cancer, but doctors have no clinical way to predict which women,” said Anda Vlad, MD, PhD, assistant professor of obstetrics, gynecology and reproductive sciences at MWRI. “If further studies show that the genetic pathway we uncovered is indicative of future cancer development, then doctors will know to more closely monitor certain women and perhaps take active preventative measures, such as immune therapy.”
Endometriosis is a painful condition that is often misdiagnosed for years before some form of correct treatment is attempted. As redOrbit reported in February, it is called a disease of theories, because so little is known about how it works, or who it will strike.
“We know there is a genetic component, we know there is an environmental component, and we know there is an inflammatory component. But it’s very difficult to say for individual patients what particular sequence of events led to particular symptoms,” Michael Beste, a postdoc in MIT’s Department of Biological Engineering, said.
It is the genetic component, and its association to cancer, that Vlad and her team are focused on finding.
Vlad and her team screened tissue samples from women with benign endometriosis, women with precancerous lesions and women with endometriosis-associated ovarian cancer. This allowed the researchers to identify the complement pathway, which refers to a series of protein interactions that trigger an amplified immune response, as the most prominent immune pathway that is activated in both endometriosis and endometriosis-associated ovarian cancer.
“If, as our study indicates, a problem with the immune system facilitates cancer growth through chronic activation of the complement pathway, then perhaps we can find ways to change that and more effectively prime immune cells to fight early cancer, while controlling the complement pathway,” said Swati Maruti Suryawanshi, PhD, a post-doctoral research fellow at MWRI.
Source: April Flowers for redOrbit.com - Your Universe Online
Topics: Health Medical Pharma, Endometriosis, Menstrual cycle, Medicine, American Association for Cancer Research, Health, Cancer, ovarian cancer
Read more at http://www.redorbit.com/news/health/1113114048/endometriosis-and-ovarian-cancer-040514/#XMkO89uv8p3qqxHf.99
Thursday, April 17, 2014
Safety and Effect on Quality of Life of Laparoscopic Douglasectomy with Radical Excision for Deeply Infiltrating Endometriosis in the Cul-de-Sac.
J Laparoendosc Adv Surg Tech A. 2014 Mar;24(3):165-70. doi: 10.1089/lap.2013.0270.
Safety and Effect on Quality of Life of Laparoscopic Douglasectomy with Radical Excision for Deeply Infiltrating Endometriosis in the Cul-de-Sac.
Abstract
Abstract Objective: To evaluate the safety and effects on health-related quality of life (HRQOL) of radical excision of deeply infiltrating endometriosis (DIE) in the cul-de-sac. Patients and Methods: This study included 390 patients with pathologically proven DIE in the cul-de-sacwho underwent laparoscopic surgery between January 2000 and December 2011. The preoperative and postoperative visual analog scale (VAS) pain scores and HRQOL data from the 36-item Short Form (SF-36) questionnaire were recorded in 343 patients. Surgical outcomes, complications, and HRQOL were compared between patients who underwent hysterectomy and those who did not. Data were analyzed using the paired t test, Student's t test, and Pearson's correlation analysis. Results: In the group overall, the VAS pain score and all SF-36 scales improved after surgery. In patients who underwent hysterectomy, all SF-36 scales improved except physical functioning, role-physical, general health, and vitality. In patients who did not undergo hysterectomy, all SF-36 scales improved except general health. There were significant associations between gonadotropin-releasing hormone agonist therapy and SF-36 mental health, SF-36 mental component summary, and oral medication use. The VAS pain score and SF-36 body pain score showed the greatest improvement, and the SF-36 general health score showed the least improvement. Patients who underwent hysterectomy had more severe disease and poorer surgical outcomes than those who did not undergo hysterectomy. Conclusions: Laparoscopic radical excision of DIE in the cul-de-sac is safe and significantly improves HRQOL, especially in terms of pain. The severity of endometriosis may affect the degree of improvement in HRQOL scores.
- PMID:
- 24625348
- [PubMed - in process]
Wednesday, April 16, 2014
Researchers to present at the World Congress on Endometriosis in Brazil
Wednesday, April 16, 2014 - 00:48 Updated 4 hours ago
Dr. Nalini Santanam, a professor in the Department of Pharmacology, Physiology and Toxicology, and biomedical sciences doctoral student Kristeena Ray said they are looking forward to participating in the conference, which is being held April 30-May 3.
"Though 10 to 15 percent of young women suffer from endometriosis and almost two-thirds of these women suffer from chronic pain, the exact nature of this disease is not very well understood. My laboratory has a long-standing interest in understanding why some women get endometriosis and have pain," said Santanam. "We are very honored that our abstracts were chosen for presentation at this meeting. The most exciting part was to find out that Kristeena was selected to give an oral presentation and was one of only six investigators selected to receive the Rodolphe Maheux Travel Grant."
Friday, April 11, 2014
Vitamin D and female fertility
Curr Opin Obstet Gynecol. 2014 Apr 8. [Epub ahead of print]
Vitamin D and female fertility.
Abstract
PURPOSE OF REVIEW:
Apart from the well known effects of vitamin D on maintaining calcium homeostasis and promoting bone mineralization, there is some evidence suggesting that vitamin D also modulates human reproductive processes. We will review the most interesting and relevant studies on vitamin D and female fertility published over the past year.
RECENT FINDINGS:
In the past year, several observational studies reported a better in-vitro fertilization outcome in women with sufficient vitamin D levels (≥30 ng/ml), which was mainly attributed to vitamin D effects on the endometrium. One randomized controlled trial found an increased endometrial thickness in women with polycystic ovary syndrome (PCOS) receiving vitamin D during intrauterine insemination cycles. Further, vitamin D supplementation had a beneficial effect on serum lipids in PCOS women. Vitamin D treatment improved endometriosis in a rat model and increased vitamin D intake was related to a decreased risk of incident endometriosis. Vitamin D was also favorably associated with primary dysmenorrhea, uterine leiomyoma, and ovarian reserve in late reproductive aged women.
SUMMARY:
In women undergoing in-vitro fertilization, a sufficient vitamin D level (≥30 ng/ml) should be obtained. Vitamin D supplementation might improve metabolic parameters in women with PCOS. A high vitamin D intake might be protective against endometriosis.
- PMID:
- 24717915
- [PubMed - as supplied by publisher]
MIT bioengineer works to unravel endometriosis
By Carolyn Y. Johnson / Globe Staff
Linda Griffith, a biological engineer at MIT who used a new technique to begin to unravel the molecular cause of endometriosis.
For four years, MIT bioengineer Linda Griffith has been slowly unraveling the biology of endometriosis, a complicated and poorly understood disease that she has silently struggled with her entire life. The condition—in which tissue normally found in the uterus grows elsewhere in the body—is remarkably common. It causes severe pain and infertility and affects up to 10 percent of women, yet relatively little is known about what causes it, how to prevent it, or even how to effectively treat it.
Thursday, April 10, 2014
Endometriosis symptoms and pain written off too often
By ASHLEIGH GLEESON Health
A HUNTER woman who once menstruated through her belly button is sharing her personal story to raise awareness about endometriosis.
Naomi Weatherburn, 46, suffered from painful periods ever since she was a teenager.
But despite the condition being so common – approximately one in 10 women have it – the GPs and gynaecologists she visited told her some level of pain was normal and she would just have to endure it.
It wasn’t until Ms Weatherburn was married and stopped taking the pill because she wanted to get pregnant that she was diagnosed with endometriosis."
Wednesday, April 09, 2014
Author Hilary Mantel: 'It won’t all be novels now — it could be plays' ~ Writes with severe Endometriosis
"Mantel has written about the severe endometriosis that doctors failed to diagnose in her youth; how it caused the loss of her fertility and the doubling of her body weight in less than a year.
Now she says the condition defined her as a writer, indeed made her one. “You really live on the verge of panic because you don’t know what’s going on inside you. And when the pain isn’t there, you know it’s waiting for you. It’s why I became a writer in the first place. I don’t like to let people down and I couldn’t have gone into an office every day.
“Sometimes I’ve travelled [to author events] and gone on stage when any sensible person would have stayed at home. I have sat in car parks thinking, ‘Do I go in and do the talk or do I go to A&E?’"
UPCI/MWRI researchers to present results of immune gene profile exploring endometriosis and cancer
Some women with endometriosis, a chronic inflammatory disease, are predisposed toovarian cancer, and a genetic screening might someday help reveal which women are most at risk, according to a University of Pittsburgh Cancer Institute (UPCI) study, in partnership with Magee-Womens Research Institute (MWRI).
Monday at the American Association for Cancer Research (AACR) Annual Meeting 2014, UPCI and MWRI researchers will present the preliminary results of the first comprehensive immune gene profile exploring endometriosis and cancer.
"A small subset of women with endometriosis go on to develop ovarian cancer, but doctors have no clinical way to predict which women," said senior author Anda Vlad, M.D., Ph.D., assistant professor of obstetrics, gynecology and reproductive sciences at MWRI. "If further studies show that the genetic pathway we uncovered is indicative of future cancer development, then doctors will know to more closely monitor certain women and perhaps take active preventative measures, such as immune therapy."
Tuesday, April 08, 2014
Monday, April 07, 2014
Sunday, April 06, 2014
Lupron Side Effects ~ Tell you Lupron Story on Erin Brockovich Site ~ Read others stories
Lupron Side Effects
For far too long now, I have been contacted by people who tell me that they have been adversely impacted by Lupron. In fact, since 1999, the FDA has received adverse drug reports about Lupron from in excess of 4,000 women and approximately, 3,000 men. According to the FDA, in 325 of those cases, hospitilization was necessary and 25 women died, directly related to Lupron use.
The shared stories on this site reveal lives that have been irreparably damaged. We need to do something about this. Nothing is more powerful in coercing change than the voices of the people. I hope that this site is a place where you can come and share your story and thoughts. This is a place where you can link to other Facebook groups, read blogs and learn about what rights you may have and current news on the Lupron. This is a place where we can become stronger together.
- See more at: http://www.lupronsideeffects.net/#sthash.BMD1RGV9.dpufhttp://www.lupronsideeffects.net/
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