Endometriosis ~ Abdominal Pain ~ Endo ~ Scar Tissue ~ Adhesions ~ Infertility ~ Hysterectomy

Saturday, December 30, 2006

Environmental and host-associated risk factors in endometriosis and deep endometriotic nodules: A matched case-control study.

Environ Res. 2007 Jan;103(1):121-9. Epub 2006 Jun 15.

Heilier JF,
Donnez J,
Nackers F,
Rousseau R,
Verougstraete V,
Rosenkranz K,
Donnez O,
Grandjean F,
Lison D,
Tonglet R.
Industrial Toxicology and Occupational Medicine Unit, Universite catholique de Louvain, 30.54 Clos Chapelle aux Champs B-1200 Brussels, Belgium.
Peritoneal endometriosis (PE) and deep endometriotic nodules (DEN) are gynecological diseases recently shown to be associated with elevated serum concentrations of organochlorines. The objective of the present study was to compare risk factors associated with both forms of the disease, with a particular attention to potential sources of organochlorine exposure. This matched case-control study with prospective recruitment included 88 triads (PE-DEN-control). All women were face-to-face interviewed with a standardized questionnaire, and serum dioxin and polychlorinated biphenyl measurements were available for 58 of them. Alcohol consumption (odds ratio (OR): 5.82 [confidence interval at 95% (95%CI) 1.20-28.3]) in DEN and low physical activity at work for DEN (OR: 4.58 [95%CI 1.80-11.62]) and PE (OR: 5.61 [95%CI 1.90-16.60]) were traced as significant risk factors. Organochlorine-related factors (use of tampons, occupational or environmental exposure) were not related to the disease. The current consumption of foodstuffs that were more likely to contribute to organochlorine body burden did not differ among the groups. Only some of these fatty foodstuffs (marine fish, pig meat) were traced by multiple regression analysis as significant determinants of organochlorine body burden, explaining only a small fraction (20%) of the interindividual variation of organochlorine body burden. We conclude that PE and DEN share similar patterns of risk or protective factors.
PMID: 16781705 [PubMed - in process]

Increased dioxin-like compounds in the serum of women with peritoneal endometriosis and deep endometriotic (adenomyotic) nodules. [Fertil Steril. 2005] PMID: 16084869
Organochlorine exposure and the risk of endometriosis. [Fertil Steril. 1998] PMID: 9496332
NTP Toxicology and Carcinogenesis Studies of 2,3,4,7,8-Pentachlorodibenzofuran (PeCDF) (CAS No. 57117-31-4) in Female Harlan Sprague-Dawley Rats (Gavage Studies). [Natl Toxicol Program Tech Rep Ser. 2006] PMID: 17160103
Serum dioxin-like compounds and aromatase (CYP19) expression in endometriotic tissues. [Toxicol Lett. 2006] PMID: 17112691
NTP technical report on the toxicology and carcinogenesis studies of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (CAS No. 1746-01-6) in female Harlan Sprague-Dawley rats (Gavage Studies). [Natl Toxicol Program Tech Rep Ser. 2006] PMID: 16835633

No comments: